Changing Your Diet Can Add 10 Years to Your Life

Everyone wants to live longer. And we’re often told that the key to doing this is making healthier lifestyle choices, such as exercising, avoiding smoking and not drinking too much alcohol. Studies have also shown that diet can increase lifespan.

This article is a repost which originally appeared on ThePrint
Laura Brown - February 20, 2022
Edited for content and readability - Images sourced from Pexels 
Study Source: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003889

Our Takeaways:

  • An optimal diet includes more legumes (beans, peas and lentils), whole grains (oats, barley and brown rice) and nuts, and less red and processed meat.
  • Gains from changing from a western diet to the optimal diet are largest if the diet changes start early in life.
  • Eating the optimal diet from age 20 would increase life expectancy by more than a decade for women and men from the US, China and Europe.
  • At age 60, life expectancy is increased by eight years. At age 80, life expectancy is increased by almost three and a half years.

new study has found that eating healthier could extend lifespan by six to seven years in middle-aged age adults, and in young adults, could increase lifespan by about ten years.

The researchers brought together data from many studies that looked at diet and longevity, alongside data from the Global Burden of Disease study, which provides a summary of population health from many countries. Combining this data, the authors were then able to estimate how life expectancy varied with continuous changes in intake of fruit, vegetables, whole grains, refined grains, nuts, legumes, fish, eggs, dairy, red meat, processed meat and sugary drinks.

The authors were then able to produce an optimal diet for longevity, which they then compared with the typical western diet – which mostly contains high amounts of processed foods, red meat, high-fat dairy products, high-sugar foods, pre-packed foods and low fruit and vegetable intake. According to their research, an optimal diet included more legumes (beans, peas and lentils), whole grains (oats, barley and brown rice) and nuts, and less red and processed meat.

The researchers found that eating an optimal diet from age 20 would increase life expectancy by more than a decade for women and men from the US, China and Europe. They also found that changing from a western diet to the optimal diet at age 60 would increase life expectancy by eight years. For 80-year-olds, life expectancy could increase by almost three and a half years.

But given it isn’t always possible for people to completely change their diet, the researchers also calculated what would happen if people changed from a western diet to a diet that was halfway between the optimal diet and the typical western diet. They found that even this kind of diet – which they called a “feasibility approach diet” – could still increase life expectancy for 20-year-olds by just over six years for women and just over seven years for men.

These results show us that making long-term diet changes at any age may have substantial benefits to life expectancy. But the gains are largest if these changes start early in life.

Full picture?

The life expectancy estimates this study makes come from the most thorough and recent meta-analyses (a study that combines the results of multiple scientific studies) on diet and mortality.

While meta-analyses are, in many cases, the best evidence because of the amount of data analysed, they still produce assumptions with the data, which may cause important differences between studies to be ignored. It’s also worth noting that the evidence for reducing consumption of eggs and white meat was of a lower quality than the evidence they had for whole grains, fish, processed meats and nuts.

There are also a few things the study didn’t take into account. First, to see these benefits, people needed to make changes to their diet within a ten-year period. This means it’s uncertain if people may still see benefits to their lifespan if they make changes to their diet over a longer period of time. The study also didn’t take past ill-health into account, which can affect life expectancy. This means that the benefits of diet on life expectancy only reflect an average and may be different for each person depending on a variety of other factors, such as ongoing health issues, genetics and lifestyle, such as smoking, drinking alcohol and exercise.

But the evidence the researchers looked at was still robust and drawn from many studies on this subject. These findings also align with previous research which has shown that modest but long-term improvements to diet and lifestyle can have significant health benefits – including longevity.

It’s not yet entirely clear all the mechanisms that explain why diet can improve lifespan. But the optimal diet that the researchers uncovered in this study includes many foods that are high in antioxidants. Some research in human cells suggests that these substances may slow or prevent damage to cells, which is one cause of ageing. However, research in this area is still ongoing, so it’s uncertain whether antioxidants that we consume as part of our diet will have the same effect. Many of the foods included within this study also have anti-inflammatory properties, which may also delay the onset of various diseases – and the ageing process.

Of course, changing your diet completely can be difficult. But even introducing some of the foods shown to increase longevity may still have some benefit.

David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast

David Sinclair is a geneticist at Harvard and author of Lifespan.

This Podcast is a repost which originally appeared on lexfridman.com
Podcast notes are a repost which originally appeared on PodcastNotes
Lex Fridman Podcast #189 with David Sinclair - June 6, 2021
Edited for content and readability - Images sourced from Pexels

Key Takeaways

  • Wearables have the potential to revolutionize medicine
  • The goal is doctors being able to look at a dashboard of our body based on swabs, blood tests, and biosensors and make real-time, tailored recommendations
  • Top causes of aging: broken chromosomes, cell stress, smoking
  • Lifestyle methods to slow aging: fasting (skip 1-2 meals per day), eat more vegetables and less red meat, exercise, get good quality sleep (quality more important than quantity)

Introduction

Dr. David Sinclair (@davidsinclair) is a biologist, professor of genetics at Harvard, author, and expert on aging and longevity. His research and biotech companies focus on understanding why we age and how to slow its effects.

In this episode of the Lex Fridman Podcast, Lex and guest David Sinclair discuss the determinants of why we age, solving aging, the trend of wearables and tracking health data, artificial intelligence, social perspectives of lifespan , and death, and lifestyle factors to improve lifespan.

Host: Lex Fridman (@lexfridman)

Book: Lifespan: Why We Age and Why We Don’t Have To by David Sinclair

Artificial Intelligence & Immortality

  • We live in a time we can leverage data to have the pieces of the life of people we can gather using technology, beyond just written books
  • AI makes it possible to bring back people that we love in some way and in essence achieve immortality
  • AI can be used to build experience, thoughts, speech
  • AI uses in aging: generate biological clocks, predict protein folding, assemble genomes, predict longevity in mouse in response to stimuli, diagnosing a virus

David Sinclair Interest And Predictions On Wearables

  • Wearables represent the merging of machines and humans  
  • Wearables help us collect biological data about our bodies
  • We can use data to keep ourselves in optimal shape
  • “Picture a future where you’re monitored constantly so you wouldn’t have a heart attack, you’d know that was coming.” – David Sinclair
  • It’s feasible that wearables and similar technology will indicate what antibiotic or medication to take, what to eat, etc. – and augment physicians who would just need to sign off on the protocol
  • COVID-19 accelerated biological technologies & medical advances
  • There will be day doctor’s use wearable technology to send patients home for monitoring instead of keeping them in the hospital
  • Wearables will revolutionize medicine – it can collect data which can be used to predict sickness, diagnose disease

InsideTracker

  • InsideTracker: David Sinclair co-founded a company that creates personalized and actionable plans to help people optimize their bodies through nutrition, supplements, and lifestyle
  • Connects scientific papers to individual data and make recommendations for lifestyle
  • InsideTracker leverages hundreds of thousands of human data points and thousands of scientific articles to create a formula of what works and what doesn’t for your body
  • Recommendation of food and nutrition was better than leading drug at treating type 2 diabetes
  • Soon, the current model of medicine is going to outdated as machines and data will know us better than our doctor
  • “We wouldn’t drive a car without a dashboard so why would doctors do the same?” – David Sinclair

How And Why We Age

  • Aging is both a feature and bug of evolution
  • We only need to live as long as we need to in order to replace ourselves – some breed slowly and build a body that lasts, some breed quickly and die quickly
  • We can do better at aging
  • Hallmarks of aging include: loss of telomeres, senescent cells, loss of energetics
  • Defining factor of aging: preservation of information and loss of entropy
  • “Loss of information in our bodies is a root cause of aging.” – David Sinclair
  • We have information regulator genes in our bodies – upregulation could preserve health
  • Information in cells = DNA and epigenome
    • DNA is usually intact in animals and humans over time
    • Epigenome: regulators of genetic information
  • Question of importance: is there a repository of information in the body to restore from?
  • Antagonistic pleiotropy: a system built to keep us alive when we’re young but has damaging effects later in life
  • Causes of aging: (1) broken chromosomes and (2) cell stress – smoking also dramatically accelerates biological age
    • It’s hard to repair something that’s constantly breaking: we have 1000 chromosome breaks per day – the break is recognized by proteins and is usually fixed but not always
  • You can slow down aging using three embryonic genes to reset the age of tissues to a certain point – but if you don’t do it right it can cause tumors  

Data Sharing In Biology

  • “We’re living through what’s going to be seen as one of the biggest revolutions in human health through the gathering of data about our bodies.” – David Sinclair
  • Ultimately, we’re all going to be monitored
  • There will be a reversal where blamed will be assigned for not collecting data
  • Decisions are made based on very few tests when we have the opportunity to collect more
  • Consumer health is going in the direction of the patient having access to better data than the doctor (through private lab tests, biotech companies, etc.)
  • Doctors are becoming excited and interested about seeing and using privately collected patient data to make more informed decisions
  • The U.S. currently spends 17% of GDP on healthcare – we can save money by monitoring using wearables and prevention
  • Ideally, we can create a system where we can share data as we’d like and keep what we wouldn’t

Lifestyle Methods To Slow Aging

  • Fasting is one of the oldest ways to improve health – we need to optimize how long and the frequency
  • “If there’s one thing I can recommend to anybody to slow down aging it’s to skip a meal or two a day.” – David Sinclair
  • Note: David Sinclair is a big fan of one meal a day; the carnivore diet has made Lex feel really good
  • When you eat seems to be more important than what you eat
  • Data says plant-based foods are better than meat-based foods
    • People who live longer tend to eat Mediterranean diets with little red meat
    • High meat consumption stimulates mTor
    • Could take rapamycin to counteract effects of meat
    • Meat produces immediate health benefits (muscle, energy) but potentially at the expense of long term effects
  • Eat a diet full of leafy greens, avoid spikes in sugar, possibly explore supplementing with resveratrol
  • Exercise clearly extends longevity
  • You don’t need much exercise to get great benefit – exercise aerobically a few times per week (even 10 minutes) and lift weights a few times per week
  • Sleep is critical for longevity to avoid premature aging and adverse health outcomes
  • Sleep quality seems to matter more than quantity
  • The brain is the center for longevity so we have to take care of stress levels, mental health

Data Collection Methods

  • We’ll likely work to moving away from blood draws for data
  • Currently: swab and ship to the lab to test hormones, stress levels, blood glucose, etc.
  • In the next 10 years: spit on paper and stick in a machine for analysis
  • Home tests are really easy and scalable if they can become democratized (price reduced)

Realistic Goals Of Lifespan

  • If you start eating cleaner in your 20s, that has been shown to improve lifespan in animal models
  • If you are in your 20s, aim to reach 100
  • There’s no maximum limit to human lifespan

Death & Denial

  • We seem to draw meaning from life being rooted in our existence – most of us find it distressing to face our own mortality
  • All living beings have evolved to want to live and survive
  • It’s possible we evolve to naturally deny aging because we need to use our energy and focus for innovation and life instead of death
  • It might be easier to be lazy if you are immortal

Note: Wearable Oura ring was referred to multiple times throughout the show

Promising Anti-Aging And Longevity Molecules

Posted on Jan 11, 2022, 4 p.m.

This article is a repost which originally appeared on WORLD HEALTH.NET

Edited for content

Regenerative, anti-aging, and longevity researchers have been working to find molecules that can help to improve and/or extend both human health and lifespan. This article gathers information on some of the most promising molecules to extend human healthspan and possibly lifespan. There are also a few honorable mentions at the end of the article. 

This list is heavily influenced by the Interventions Testing Program (ITP). This program selects a variety of different molecules each year to see which ones will extend mice’s lifespan. They use mice that are genetically heterogeneous, all this means is that the mice are genetically diverse and therefore minimize the possibility that characteristics of a single type of mice would affect the results. They also run these experiments at three separate labs, this is to figure out if the results are true and reproducible. 

The first molecule is called glycine. When the Interventions Testing Program trialed glycine it led to a four to six percent increase in lifespan for both males and females. Now bear with me because we need to unpack this. Glycine along with another molecule called NAC (N-acetylcysteine) are building blocks for a powerful antioxidant called glutathione. In humans, the glutathione antioxidant system is maintained until around 45 years of age and then it declines rapidly. But in a 2021 human trial glycine and NAC supplementation for 24 weeks corrected the glutathione deficiency. By using glycine and NAC we can restore the glutathione balance, and now we’ve got human data showing a positive benefit for health. 

A 2021 human trial of a group of molecules called the combined metabolic activators (CMAs)  that do consist of glutathione precursors, use cuts the recovery time from COVID-19 by a whopping three days when compared to placebo. In that trial to support glutathione, they did use NAC but instead of using glycine, they used another molecule called serine. Serine is just converted into glycine by the body. Overall though for the first molecule, it’s actually a combination of precursors to rebuild glutathione. The combination of glycine or serine and NAC.

Next up is nicotinamide riboside. As part of the combined metabolic activators, it also included nicotinamide riboside to help rebuild a molecule called NAD. This is important because new research has come out showing that after the age of around 60 years old our metabolism appears to tank and NAD is central to our metabolism. By rebuilding our NAD stores, we’re hopefully helping to support our metabolism and therefore improve our resiliency against diseases. 

When the Interventions Testing Program trialed nicotinamide riboside it did not extend lifespan. But much of the excitement around nicotinamide riboside is not to do with its potential of lifespan extension, instead, it’s because we can support our metabolism with it, which can make us more resilient against metabolic attacks. For example, sunlight, alcohol, and time zone disruption, all these things attack our metabolism, and by taking the nicotinamide riboside we may be more resilient against these attacks and that’s possibly why we can see an improvement in the recovery time of COVID-19 patients. 

The third molecule is 17-alpha estradiol which is a non-feminizing type of estrogen. When the Interventions Testing Program trialed it, it extended male mice’s lifespan by 19%. To stress again this is a non-feminizing type of estrogen, this is important because estrogenic actions have been increasingly recognized to have potential health and anti-aging benefits. It’s not just males that seem to get a benefit from this molecule, in female mice, there’s a 20% reduction in body weight. We are very excited to read more human data about this molecule.

Moving on to the fourth molecule on the list we’ve got SGLT2i inhibitors. This is a class of medication that is routinely prescribed to type 2 diabetic patients. When the Interventions Testing Program trialed it, it extended male mice lifespan by 14%. In humans, a 2019 systematic review was published in The Lancet journal looking specifically at heart disease outcomes involving over 34 000 patients, and what we could see in this study is that SGLT2i inhibitors reduced heart attacks by 11% and reduced the progression of kidney disease by 45%. 

This medication works by encouraging the kidneys to pee out sugar, instead of that sugar remaining in the bloodstream, it’s eliminated out of the system. This is important because it blunts the peak blood sugar levels which may be a factor in the lifespan extension effects that we see from the Interventions Testing Program. The potential for this molecule is because as we age our kidney function declines even from our mid-20s, and we’ve got human data showing that for non-diabetic kidney disease patients this type of medication does delay the progression of kidney disease. So I do wonder whether this class of medication would be used to the wider population to slow down kidney disease and therefore extend healthspan.

The fifth molecule that there is excitement about is rapamycin. Rapamycin is the golden egg from the Interventions Testing Program. Over and over again when they trial this molecule it extends both female and male lifespan, and that is why I’ve chosen to study this molecule. In a clinical trial, I want to figure out if using rapamycin once a week combined with exercise gives even greater muscle performance benefits compared to just exercise alone.

There are also three other molecules that almost made the top five list. The first one is fisetin. Essentially as we age some of our cells stop dividing and they become senescent. Fisetin does hold the potential to clear away those old cells, and that’s important because those old cells don’t just remain dormant they also release all sorts of factors that can damage our body. The Interventions Testing Program as part of their 2018 group of molecules will be trialing fisetin, and the Mayo Clinic have turned their attention to running human fisetin trials.

The second honorable mention is alpha-ketoglutarate (AKG), this molecule generated quite the hype in 2020 where a mice trial showed a 16.6% improvement in lifespan. We are all eagerly awaiting more human data to come out on this molecule to see whether it will improve human health.

The final honorable mention is hyaluronic acid. The quantity of hyaluronic acid gradually declines as we age, and hyaluronic acid is a major component of the connective tissue of the body including our blood vessels, skin, and organs. In a 2021 human 12-week double-blind placebo-controlled study we can see that hyaluronic acid significantly improved skin elasticity. If hyaluronic acid can improve skin health (wrinkles and dry skin) maybe it can improve blood vessel health and other parts of the body. Additionally, hyaluronic acid may also be the underlying reason as to why the naked mole rat has such exceptional longevity.

There we have an evidence-based list of top promising anti-aging and longevity molecules. But it is worth mentioning that this article is only partial, there are many others being studied looking for that elusive “fountain of youth” to help improve the human condition. 

As with anything you read on the internet, this article should not be construed as medical advice; please talk to your doctor or primary care provider before making any changes to your wellness routine.

Content may be edited for style and length.

Materials provided by:

This article was adapted from a presentation by Dr. Brad Stanfield

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