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New insights into how the ‘first brain’ works in the gut


This article is a repost which originally appeared on ScienceDaily

Flinders University – August 15, 2021

Edited for content and readability
Images sourced from Pexels

DOI: 10.1038/s42003-021-02485-4

New research explains how the gut nervous system causes propulsion

There is new research that explains how the nervous system in the gut, known as the enteric nervous system (ENS) causes propulsion along the gut. This highlights how similar it behaves to other neural networks in the brain and spinal cord.

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The Study

The study, led by Professor Nick Spencer at Flinders University, maintains that the ENS in the gut is the ‘first brain’ and that it evolved long before the brain as we know it, in humans. The new findings uncover major new information about how the many thousands of neurons in the ENS communicate with each other. This interaction can cause the muscle layers to contract and propel content. Until now, this had been a major unresolved issue.

In a new paper in Communications Biology (Nature), Flinders University Professor Nick Spencer, says the latest findings are far more complex than expected. The findings are also considerably different from the mechanisms that underlie the propulsion of fluid along other muscle organs that have evolved without an intrinsic nervous system. Examples include the lymphatic vessels, ureters, or the portal vein.

“Synchronisation of neuronal activity across large populations of neurons is common in the nervous system of many vertebrate animals,” Professor Spencer says.

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The Results

The researchers took advantage of a recent technical advance from their laboratory which enabled them to record the smooth muscle electrical activity along the length of colon at the same time as correlating electrical activities with dynamic changes in colonic wall diameter, during propulsion.

This process has revealed a key new mechanism that finally explains how all the different types of neurons in the ENS come together and coordinate the firing to generate propulsion of content along the colon.

“Interestingly, the same neural circuit was activated during both propulsive and non-propulsive contractions.”


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