fat pad and visceral fat

[Pegasus]

Finding stuff like this which indicate type of fat eaten has implications.

This study evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oxidative stress and energy metabolism parameters in the visceral fat of a high-fat-diet induced obesity model. Energy intake, body mass, and visceral fat mass were also evaluated. Male Swiss mice received either a control diet (control group) or a high-fat diet (obese group) for 6 weeks. After this period, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + omega-3, and to these groups 400 mg·(kg body mass)-1·day-1 of fish oil (or saline) was administered orally, for 4 weeks. Energy intake and body mass were monitored throughout the experiment. In the 10th week, the animals were euthanized and the visceral fat (mesenteric) was removed. Treatment with omega-3 PUFAs did not affect energy intake or body mass, but it did reduced visceral fat mass. In visceral fat, omega-3 PUFAs reduced oxidative damage and alleviated changes to the antioxidant defense system and the Krebs cycle. The mitochondrial respiratory chain was neither altered by obesity nor by omega-3 PUFAs. In conclusion, omega-3 PUFAs have beneficial effects on the visceral fat of obese mice because they mitigate changes caused by the consumption of a high-fat diet.




[FONT=&quot]Visceral fat accumulation is associated with metabolic disease. It is therefore relevant to study factors that regulate adipose tissue distribution. Recent data shows that overeating saturated fatty acids promotes greater visceral fat storage than overeating unsaturated fatty acids.[/FONT]

 

[Ashealth]

I was reading about this most recent study that was done for diabetes but they found that TSLP-treated mice also decreased their visceral fat mass.

Here's the link to the article I read:https://scitechdaily.com/reversing-...t-causes-mice-to-lose-weight-by-sweating-fat/

Here's the actual study: https://science.sciencemag.org/content/373/6554/eabd2893

 

[Pegasus]

I was reading about this most recent study that was done for diabetes but they found that TSLP-treated mice also decreased their visceral fat mass.

Here's the link to the article I read:https://scitechdaily.com/reversing-...t-causes-mice-to-lose-weight-by-sweating-fat/

Here's the actual study: https://science.sciencemag.org/content/373/6554/eabd2893

Tslp was increased by genetic manipulation I don't see any use for this in the short to medium term .
Thanks for the input though.

 

[Pegasus]

Ok so my conclusions insulin (try to keep it down ) test (try to keep it up)cortosiol(try to keep it down) to control core fat . Also type of diet eg type of fats eaten may have an effect . Aerobic exercise over 60% max heart rate seems to help also.

The Effect of Exercise on Visceral Adipose Tissue in Overweight Adults: A Systematic Review and Meta-Analysis

Excessive visceral adipose tissue appears to trigger a cascade of metabolic disturbances that seem to coexist with ectopic fat storage in muscle, liver, heart and the ß-cell. Therefore, the reduction of visceral adipose tissue potentially plays ...

www.ncbi.nlm.nih.gov

 

[Big Al]

Controlling starches and sugars is often the biggest problems for issues like this. Sticking to mostly leafy greens and other vegetables (sparing on the starchy veg.) is good for this.

 

[Pegasus]

Yes Al so controling insulin is a part of this . Another diet tip that has come up is avoiding trans fats .

 

[Pegasus]

By Susannah Chen​

A newly published study found that type 2 diabetes is not attributed to having obesity as defined by BMI. Rather, each individual’s genetics determine whether or not they have become too heavy for their body and have too much fat inside the pancreas and liver than they can tolerate.
The onset of type 2 diabetes is not attributed to having obesity as defined by body mass index (BMI), a new study has found. It’s actually caused by having more fat inside the liver and pancreas than that particular person can handle.
Dr. Roy Taylor, professor of medicine and metabolism at the University of Newcastle School of Medicine in England and lead investigator for the study, discussed the newly published results of the ReTUNE trial at the 59th European Association for the Study of Diabetes in Hamburg, Germany.

The ReTUNE Trial in Type 2 Patients Without Obesity​

The trial recruited 20 participants who had been diagnosed with type 2 diabetes within the past 6 years, were not on insulin, and who had a body mass index in the “healthy weight” category. (Since other types of diabetes, such as type 1 autoimmune diabetes and monogenic diabetes, are more common in this weight group, participants were also screened to ensure that other forms of diabetes were excluded.)
Participants then underwent cycles of weight loss to achieve a rapid body weight reduction in 5% increments. This was achieved through two to four weeks of an 800-calorie-per-day Mediterranean-style diet. These rapid weight loss cycles were followed by four to six weeks of maintenance at a stable weight. If participants’ A1Cs remained above 6.5, then they were permitted to take up to two more cycles to achieve an additional 5% body weight reduction per cycle.
Metabolic assessments were made after each weight loss cycle as well as after 12 months to determine how closely metabolic features such as blood glucose and A1C returned to normal.
“A person with type 2 diabetes has become too heavy for their own body, their own genetic constitution. “It is caused by more fat inside the liver and pancreas than can be tolerated by the individual.”The study found that most people with recently diagnosed type 2 diabetes were able to return to normal blood sugar, liver fat, and fat export levels long term, and that 70% of participants were able to achieve diabetes remission (defined as an A1C below 6.5). The bottom line? Individuals have differing susceptibility to fat excess, Taylor said. “A person with type 2 diabetes has become too heavy for their own body, their own genetic constitution. “It is caused by more fat inside the liver and pancreas than can be tolerated by the individual.”

A Blood Test For "Personal Fat Thresholds"?​

The ReTUNE trial also had a second aim: to test whether it is possible to detect that normal fat stores have been overfilled and people have exceeded their personal fat thresholds by a simple blood test, as well as whether it’s possible to see those fat stores return to normal when diabetes is put into remission. While initial data appeared promising – fat stores appeared to be elevated at the beginning of the study and decreased once A1C decreased – Taylor and his colleagues determined that more research using a larger study size is needed to determine whether this blood test has potential to be a reliable indicator.
Taylor was the lead investigator in an important trial called the DiRECT study that demonstrated that weight loss using a low-calorie diet can help put type 2 diabetes into remission in people who were recently diagnosed, and that people who have type 2 diabetes in remission can sustain it for up to five years if weight gain is avoided using a low-calorie diet.

 

[Pegasus]

Hmm this makes me wonder my genetics are greyhound even though i am lean by normal standards post 107 might still be relevant.

 

[Pegasus]

Visceral fat vs fat pad /

Ok so core fat is part of total body fat so I think it is safe to say fat pad is part of core fat . So part of core fat is visceral fat which is particularly an issue for health . So just puting it out there my fat pad seems to track my visceral fat . Looking for comment

thebiohacker.com

 

[Pegasus]

Spot reduction *read before comment *

Ok so I had a dexa some years ago and it was pretty normal . I was carrying more muscle than most but then I do weights and am generally active So some months back I had an injury to my left hip which droped my activity for a month including a week of bedrest. Not only did I lose a lot of...

thebiohacker.com

 

[Pegasus]

I can discuss my latest dexa here if there is interest.

 

[Pegasus]

Ok so latest dexa shows I gained 4 ib odd of muscle lost 4 lb of fat which is a good trick over the 7 month odd period. So this is a good result all considered . My bone density went up which is a good result and interesting given my age and that it was already high . Only negative was i gained visceral fat .

 

[Big Al]

This is good news!

Visceral fat is often more of a hormone response as well as a tendency during aging. Not impossible to deal with, but can prove difficult. This may require a shift to lower glycemic index foods.

 

[Johnny D]

Again... Interval sprints. Just sayin

 

[Pegasus]

While there is no particular evidence that interval sprints work (or don't work) there is evidence that work beyond 60% max heart rate is effective . Mind you most of the zone 2 I have been doing is beyond that . In any case now I am more conditioned I intend to do some higher intensity work Johonny.

My food is weighted to low G AL has been for some time . The hormonal is an ongoing battle the main issue being sleep .\

 

[Johnny D]

Sleep is a huge issue for me too, Peg! I'm up at 3:30 today. WTF?! Ugh!

 

[Pegasus]

so latest dexa bodyfat was up but visceral and fatpad were down . so I think drink might be implicated

 

[BigO]

Sleep is a huge issue for me too, Peg! I'm up at 3:30 today. WTF?! Ugh!

I have the same issue. It's been good for PE but I would love to be able to sleep for 7 or 8 hours once in a while

 

[BigO]

so latest dexa bodyfat was up but visceral and fatpad were down . so I think drink might be implicated

For me, a big game changer is keeping my carbs on the lower side

 

[Johnny D]

For me, a big game changer is keeping my carbs on the lower side