What is NAD+ and what are the benefits of NAD supplements and NAD+

NAD+: is this new wonder supplement the secret to looking and feeling younger for longer?

May 23rd 2022 / Ingeborg Van Lotringen

This article is a repost which originally appeared on GET THE GLOSS

Edited for content. The opinions expressed in this article may not reflect the opinions of this site’s editors, staff or members.

Our Takeaways:

· NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring cellular component.

· NAD+ is responsible for cellular repair as well as energy.

· Exercise and fasting can raise levels of NAD+ in the body.

MOVE OVER COLLAGEN THERE’S A NEW SUPPLEMENT WITH A GROWING FAN BASE PROMISING TO HOLD BACK THE YEARS. IS NAD MORE THAN A FAD? WE ASKED DOCTORS TO WEIGH IN 

Vitamin A, collagen powders, CBD… Not a month goes by when we hear about a new ‘wonder’ ingredient that is going to blitz our ailments and hold back the years. The latest contender is NAD+ (pronounced ‘N.A.D. plus’). Already crowding the shelves of health food stores in the US, where preventative medicine and supplements are an even bigger ‘thing’ than here (and a sign of what’s heading our way!), the energy-generating co-enzyme – a compound naturally found in the body – is beginning to make waves in the UK too.

The claim is that it may improve our health and, by extension, our skin, in a myriad of ways, from giving us more energy to reducing cravings to protecting against cell damage, and much more. It’s even touted as the ultimate anti-ageing pill for its ability to keep youthful energy levels topped up, with fans including biohacker Davinia Taylor. “It helps me get rid of brain fog and actually gives me a feeling of confidence. For me, it peps up my mood and changes my mental clarity, making me feel as if I’m 20,” she told us recently.

In the US, where it’s one of the fastest-growing and buzziest supplements, people have long stopped asking what is NAD+?. “They only want to know what the best supplement is,” says molecular biologist and UK supplement entrepreneur Dr Nichola Conlon. So will it prove to be the game-changer everyone’s looking for, putting a spring in our step, making us feel and look younger or even live longer?

The doctors we spoke to were open-minded. Cosmetic physician Dr David Jack, who has his own range of supplements says: “I’ve seen numerous studies in recent years showing benefits of NAD supplementation in modulating inflammation, metabolic decline and cellular and DNA repair,” he says. “Although the evidence is in its early stages, given the low chance of side-effects it may be a very useful supplement for patients either suffering from neurodegenerative conditions or as part of an anti-ageing supplement routine”.

Let’s investigate further…

What is NAD used for?

NAD+ (sometimes called NADH or NAD) stands for nicotinamide adenine dinucleotide, a natural chemical found in every single cell in the body. Think of it like a battery. It plays a major role in generating cellular energy, as well as in the maintenance and repair of our cells, including our DNA. It’s thought to be involved in more than 500 different reactions that keep cells in good health. No biggie, then.

How does NAD+ work to help fight ageing?

If we have high levels of NAD+, it means we have lots of cellular energy – our cells function optimally and we feel more energetic and alert. It also means the body can repair itself quicker, which helps keep our organs, including our skin, in pristine working order. But just like collagen, our levels of NAD+ decline with age. It’s thought they halve every 20 years, from the day we’re born. With age, the body becomes less able to generate it, plus older and naturally more damaged cells use up NAD+ stores at a higher rate. A downward spiral of NAD+ correlates with the onset of many of the complaints associated with ageing including wrinkles, memory loss, heart problems, dementia, Parkinson’s, vision loss, and more. NAD+ decline is seen as one of the nine main hallmarks of ageing, according to Conlon.

How to increase NAD+ levels

You cannot stop the decline of your body’s ability to produce NAD+, but you can slow down the rate at which the body uses it up. Basically, the healthier you are and the less damage your cells sustain from things like disease, stress, unhealthy lifestyle choices and an unhealthy environment, the more NAD+ you have available for keeping your organs in ‘homeostasis’, i.e. strong, healthy and ‘young’ for their age. So: a good old healthy lifestyle with lots of stress management is, as per usual, the best way to keep this important powerhouse ticking over. Conlon adds that research has shown that the well-known positive benefits of exercise and fasting are down to the fact that they ignite the body’s production of NAD+. “They create an energy stress in the body, which responds by increasing NAD+ to switch on cellular maintenance and repair in order to overcome this temporary strain,” she says. “HIIT and resistance training have been found to be the most effective.”

But in the States, and increasingly over here, supplementing NAD+ is thought to be a way of off-setting its natural decline as well. “Multiple studies have demonstrated that NAD+ boosting strategies have benefits at cellular, animal and human level,” says Conlon. One study suggests that one of the ways NAD+ supplementation can do this is by activating the protection and stabilisation of telomeres, which helps prevent cell death and therefore the risk of long-term diseases setting in. Ultimately, says Conlon, “while I would stop short of saying NAD+ boosters help you live longer, it is clear they improve healthspan, which is the proportion of your life you spend in good health.”

But there is a caveat. There have been thousands of papers written on NAD+ supplementation in animals, and about 20 human studies, says Conlon. But at present, there is no conclusive, long-term proof that it can reverse or delay ageing, and it is important to keep in mind that we are talking about a nutritional supplement here, not medication. That doesn’t stop people from leaping on the chance to try it, of course, preferring to take their chances in the pursuit of a longer, healthier life.

NAD+ benefits

With most of the evidence circumstantial, anecdotal, or based on animal studies, below are some of the things that NAD+ supplementation may be good for. It is prescribed in America (and increasingly, here) by functional medicine practitioners and nutritionists to aid in the recovery of these, but again, not as medication.

NAD to improve sports performance

Due to its energy-boosting abilities (many users report an increase in energy, resilience and recovery) and positive impact on muscle function, NAD+ is popular with athletes and sports performance coaches, says Paul Leadon, co-founder of UK supplement company Hinnao Technology. It is also used (in the US at least) to help treat chronic fatigue syndrome. “I know people use it to support mitochondria (the batteries of cells) so it’s good for those with fatigue,” explains nutritional therapist Daniel O’Shaughnessy.

NAD for sleep issues, hangovers and long Covid

In one study, it was shown NAD+ seems to re-set our internal ‘body clock’. So NAD+ supplementation is sometimes used by people who want to treat jet lag and insomnia. And because it fortifies cells’ defence systems, it is used by some as a hangover cure to help protect the liver from the damage alcohol does. As O’Shaughnessy comments: “it’s used in addiction to support the withdrawal from alcohol and some drugs. It’s also being researched for long-Covid support.”

NAD+ and skin ageing

The world of aesthetics and ‘tweakments’ is keeping a beady eye on NAD as well. No wonder, as high levels of cellular energy mean that the body can more effectively prevent and clear up signs of skin ageing such as brown spots and fine lines. “Not only that, but the basic principle of ‘tweakments’ is that a level of controlled damage is inflicted on the skin, which then sets off a repairing, collagen-boosting mechanism in the skin,” says Conlon. “However, if the body is low on cellular energy, it has trouble performing this tissue repair and it won’t generate much additional collagen, leading to disappointing or even negative results. Boosting NAD+ reserves is thought to shore up this collagen supply and can therefore be the essential missing ‘prep’ step in skin rejuvenation procedures.”

NAD and symptoms of menopause

The booming menopause market is also ready to pounce. “We are super interested in the implications for menopause relief, and are chasing scientific data for this,” says Dr Conlon. “Menopause causes a huge increase in cellular ageing in a short space of time, turning off the energy and repair mechanisms that you so desperately need right at this time of life.” She says the company has lots of anecdotal feedback on NAD+ supplementation having a major impact on how women feel when they take it to offset menopausal symptoms.

“NAD+ is good at mopping up DNA damage and oxidative stress,” says O’Shaughnessy. “Supplementing it may also support memory and cognition.” That means it could help with the dreaded ‘brain fog’.

NAD and fatigue

Cosmetic physician Dr Sophie Shotter says that in her experience NAD+ works to treat tiredness, especially hormonally-related fatigue. “I definitely notice the difference when I supplement; for starters, I don’t get that mid-afternoon energy slump.”

NAD and preventing cravings

Apart from the aforementioned protective effect on the liver and delivering much-needed energy when you’ve been burning the candle at both ends NAD+ can, according to Dr Conlon, “help suppress the cravings that plague addicts of all kinds.” The theory is that this is because having enough NAD+ in your system stops the body ‘running on empty’ from substance abuse. As a result, it craves fewer ‘fresh hits’ of more stimulants.

Biohacker and author Davinia Taylor, a recovering alcoholic, recently told us that she noticed that effect after having a NAD+ IV drip. “It gets rid of any cravings. Think sugar, shopping…. I didn’t even fancy the chips I was trying to treat myself with,” she said. “It shuts down the body’s addictive mechanism and its need for a dopamine rush. It makes me feel not high, not buzzy, not wired like you would from Red Bull – but chipper. It’s like an alternative to hair of the dog that’s actually good for you, and an antidote to the fact that hangovers get worse with age. It’s an awake, clean energy that helps you deal with any stress better; that’s one of the things we get worse at as we get older, and when our hormones are on their way out. This is the ultimate energy shortcut that works for me.”

NAD supplements: what is the best way to take NAD+?

NAD IV drips

Taylor gets her drips from GP Dr Enayat of London biohacking health clinic Hum2n, who offers a ‘substance detox programme’ of five IV drips in one week, starting at £2795, and a three-drip anti-ageing protocol from £1295.
Beware, though: apart from the substantial financial investment, having these drips is also an investment in time, as they typically take three hours to infuse. Unless you take the ‘speedy’ half-hour option which, according to people we’ve spoken to has an unpleasant side effect of feeling temporary stomach and brain pressure as the active works its way into your system.

The payoff, says Leadon, who’s had NAD+ IV drips himself, is a sustained high and clarity of mind. “Drips are great to prepare for a major event or to aid recovery,” he says. “But my preference is always to supplement in a way that’s as close as possible to what the body does naturally. So a little-and-regular approach in the shape of daily oral supplementation is, in my opinion, the best way forward for sustained overall age prevention and support.” He considers the liposomal NAD+ supplement he’s about to launch, will be the next best thing (of course) to an IV drip.

NAD+ liposomal drops

Getting NAD+ into your cells is tricky. “NAD+ is a very large molecule that cannot just penetrate the skin or the mucus membranes in the mouth [ie taken under the tongue] to enter the bloodstream,” says Leadon. “And taken as a capsule, it won’t survive the gut intact.” To get around the issue, Leadon has created a nano-sized version of NAD+ and stabilised it in a ‘liposomal’ delivery system (protected in microscopic lipid bubbles). It’s been shown to go straight into the bloodstream when you place some drops of it under the tongue. “NAD+ is also very sensitive to heat damage so the drops may have to be kept in the fridge,” he says. Currently, the company is in the process of doing third party testing to back up its claims.

Supplements that help the body make NAD+

According to Conlon, getting NAD+ into the bloodstream doesn’t mean it actually gets into the body’s cells. “Right now, there’s very little proof that it can, apart from some indication that it can permeate some neuronal [brain and nervous system] cells. The exact same, by the way, goes for NAD+ IV drips,” she says.

This is why most NAD+ supplements provide not NAD+, but NAD+ precursors (since you ask – nicotinamide riboside or niagen tryptophan, or nicotinamide mononucleotide – NMN). Unlike the whole NAD+ molecule, these are readily absorbed into the system, and the body then converts them into NAD+.

But as far as Conlon is concerned, this is not enough. “Every cell in your body is like a small factory that needs power to function,” she says. “But with age, these ‘cell factories’ sustain major damage, which means the fuel you supply them with leaches away.” For her, it means that a good NAD+ supplement needs to provide a blend of nutrients that help repair and maintain your cells, alongside the fuel for making NAD+. Her Nuchido Time+ supplement is an example of this and has just been subjected to a double-blind, placebo-controlled crossover study to prove its claims. “We’ve tested the blood of human volunteers and we’ve seen an increase in NAD+ of 242 per cent in 16 days, on the basis of taking six capsules a day,” she says.

Can you take NAD when pregnant?

NAD+ is vital for normal organ development in babies but the advice is to, out of caution, hold off on taking NAD+ supplements in pregnancy. An Australian 2020 study on animals concluded that supplementing with precursor NMN improved the quality of ovarian cells in adult mammals but it’s not known what effect it had on their unborn young.

Are there any side effects of taking NAD+?

From the research so far (which has been done mostly on animals, with a few human studies), very few contra-indications have been flagged for taking supplements with NAD+ precursors, they seem to be very safe ingredients. In the human studies, 1000-2000mg of nicotinamide riboside (one popular precursor) a day had no harmful effects – and most supplements contain 250-300mg a day. However long-term effects in humans are still relatively unknown.

The verdict: is NAD+ the next big thing?

She would say so of course, but Conlon believes it is. “Whether it was Covid that inspired it or not, consumers in the UK have really embraced the idea of long-term preventative healthcare much more than they did before, and they’re looking for solutions that really hold water,” she says. “We’ve seen the popularity of collagen supplements, but the proof is dicey and few people are prepared to take the amount of collagen supplementation required to really see a difference.”

“While the research is growing, the possibilities are far-reaching because cellular energy is at the heart of longevity,” says Dr Conlon. For her, NAD+ supplementation is a way to stay mentally sharp and physically active for as long as possible throughout what are set to be longer lives than ever before.

Dr Sophie Shotter believes in NAD+ supplementation as well: “ I do recommend NAD supplements to patients, often those struggling with hormone-related energy levels,” she says. “But it’s important to note that we cannot supplement NAD directly,” she says. “I opt for NAD+ precursors, but I believe it’s also important to support our cellular ability to produce NAD+ as it decreases with age.”

Dr Shotter supplements patients as well as herself through IV drips with NADH “not a precursor but the ‘reduced’ version of NAD+; it easily converts into NAD+” she explains. She’s also a fan of the Nuchido Time+ supplement. “The fact that it has additional ingredients designed to boost both the cells’ ability to produce as well as recycle NAD+ is a real bonus,” she says. “With consistent use, I believe [supplements] can be very beneficial.”

But despite his strong interest in biohacking, this is one hack that nutritional therapist O’Shaughnessy isn’t getting behind just yet. He feels it’s expensive and certainly not a magic bullet. “NAD+ therapy should just be used as a tool,” he says. “If you’re suffering from fatigue, then it’s vital you consider the functional elements. These include being over-stressed, tackling vitamin and mineral deficiencies (particular in vegan diets which are often lacking iron, vitamin B12 and protein), digestive imbalances, sleep hygiene, food sensitivities, toxin overload, and more.” Taking NAD+ supplements, he says “will be a drop in the ocean if there are all sorts of imbalances in the body. The priority should be on addressing these.”

If you want to invest in an energy supplement, “a vitamin B complex is a cheap all-rounder,” he says. “Common sense says that we should function with optimal energy without the need for NAD+.” Try Healthspan High Strength Vitamin B Complex, £8.99.

Will studies prove him right or wrong? IS NAD+ a fad or the key to helping us age better? We’ll have to wait and see.

 

 

 

10 Free and Natural Bio-hacks

10 Free Natural Bio-hacks

The best hacks in life are free. Here Andreas Breitfeld presents the ten greatest gifts Mother Nature has given us, why they’re good for us, how to make the most of them and who knows more about them

Written by Andreas Breitfeld

Published on 04.12.2021 · 6:00 EST

This article is a repost which originally appeared on RedBull

Edited for content. The opinions expressed in this article may not reflect the opinions of this site’s editors, staff or members.

Our Takeaways:

· Exposure to sunlight for 10-15 minutes straight is useful for the body’s production of Vitamin D.

· Sleep is not only important for recovery but also for development and improvement

· “Earthing” can be used to positively charge the body

LIGHT: The conductor for our cells

What’s in it for me?

Our cells, our organs and our whole body can only work in harmony; the liver, lungs, kidneys, heart, brain, skin and muscles do have to know what each other are to make the whole system work. It all needs to be finely tuned, and the body uses hormones and messenger substances for that purpose. But the most important thing is light, which we absorb via the eyes and skin. Light is the most important conductor in our lives; the right light at the right time transforms this chaotic mass of 100 trillion cells within our body into a perfectly tuned orchestra. UV-B light is also the ingredient that our body turns into the vital vitamin D.

What should i do?

Go outside. Absorb natural light morning, noon and night, and do so with as much exposed skin as possible for 10 to 15 minutes in the afternoon. (Tip: your skin forms vitamin D when the sun is higher in the sky than 42°, so if the shadow you cast is shorter than you, all is good for vitamin D formation.) Avoid the blue light of your computer screens and/or use blue-light-blocking glasses. And while we’re on cell interplay, I’ve stopped wearing sunglasses for one reason: wearing them increases the risk of sunburn. The body is receiving two contradictory signals—shade on the eyes yet light on the skin – and just cannot deal with them properly.

Who knows more?

Dr Alexander Wunsch does. He’s the world’s most important photobiologist and there are multiple fascinating podcast episodes about him. Also, be sure to look up his channel on Vimeo. He’s also written a book about photobiology in his native German language: Die Kraft des Lichts [The Power of Light].

SLEEP: The number 1 Biohack

What’s in it for me?

It couldn’t be simpler and we can’t say it often enough: sleep better and you’ll live better. Sleep is the best, most important and most effective agent for relaxation, rest, regeneration and recovery there is. It’s the foundation upon which our performance, health and longevity are built. Sleep makes us wiser because it’s when we sort out the stuff we’ve learned that day. We get stronger and more resilient because we don’t just repair the damage that training has done but we also improve our starting condition; this is what we call the training effect. We get healthier because the lymphatic system cleanses our brain of all the waste products. Cell damage anywhere in the body is repaired, too.

The oft-used comparison of sleep to recharging your mobile battery is incorrect because we humans recharge our own battery, and more than that, we even improve our batteries’ charging capacity. And all we have to do is make sleep our top priority.

“In sleep we get smarter, we get stronger and more persistent, we get healthier. Let us make sleep the number one priority in our lives.”

Andreas Breitfeld pays attention to many small factors to maximize on sleep.

What should i do?

You can actively improve your sleep by not eating anything for the last three hours before you go to bed, switching off stimulating light impulses for the last two hours (as little screen light as possible and wear blue-light-blocking glasses) and avoiding stress in the evenings wherever possible. Your bedroom should be very dark and cool, preferably between 16°C and 20°C. Magnesium works for many people, though not all, as does ashwagandha, but give both a try. Two to three hours before going to bed, I take melatonin, the so-called sleep hormone, which can do so much more than just make us tired. Some doctors advise against it, but current studies claim that your body’s own production of it isn’t affected by you taking it. Melatonin really is worth a try.

Who knows more?

Austria’s Professor Günther Amann-Jennson has devised the Samina sleep system; it’s expensive but probably the best thing currently on the market. Amann-Jennson, a doctor and psychologist, makes lots of excellent content [in his native German] available for free on his website at einfach-gesund-schlafen.com.

EARTHING: The positive in the negative

What’s in it for me?

This may all sound like esoteric magic, but it is crystal-clear physics. Ion exchange with the negatively charged Earth reduces oxidative stress and the horribly dangerous chronic inflammation processes that come with it because it positively charges our body. (Oxidative stress is, incidentally, a turbo boost for the ageing process.) All we have to do is come into direct contact with the planet and let the electrons flow by walking barefoot in a meadow or going swimming in a natural body of water, for example. Another benefit of coming into direct contact with the Earth: the 7.83 Hertz at which the Earth vibrates is what we call the Schumann resonance and it might even reduce electromagnetic stress.

What should I do?

Take your shoes off and walk barefoot in a garden, in the woods or through a meadow. Leap into a natural body of water every now and again instead of just splashing around in the ice-bath. You can also earth when you sleep, but that’s another topic because it only makes sense to use earthing sheets or other similar items when there’s no electric smog caused by Wi-Fi and the like. Otherwise earthing will turn you into a human antenna – pretty much the exact opposite of what we’re trying to achieve here.

Who knows more?

Austria’s Marco Grosch, the self-titled minimalist bio¬hacker, has excellent knowledge of a broad range of topics in this field. One of those topics is earthing, to which he devotes his German-language website (minimalist-biohacker.com) and his Instagram feed.

BREATHING: Our brain’s remote control

What’s in it for me?

Breathing is an incredibly powerful tool; I can breathe myself into a calm state or breathe myself into a rage and frenzy. No other action has such direct access to my brain and autonomic nervous system. Try box breathing, for example – breathe in for four seconds, hold your breath for another four, breathe out for four, hold your breath for four seconds again. It helps calm the nerves. Wim Hof’s method of breathing can strengthen the immune system and, when combined with the cold, it can even relieve depression. But just by consistently breathing through your nose, not your mouth, every day, you’ve already taken a big step towards improved health.

“The mouth is there for eating, for kissing and—I know that particularly well—for talking. But not for breathing. Especially not to breathe in!”

Breitfeld says to breathe through your nose in everyday life should be the goal

What should i do?

Breath through your nose. I’ve focused a lot on this subject recently, including mouth-taping: by taping my mouth up when I go to bed, I force myself to breathe through my nose, which takes a lot of getting used to but improves my sleep. The mouth is for eating, kissing and – I know this very well – talking, but not for breathing and definitely not for breathing in. The advantages of breathing through the nose are huge. It removes particles from the air we breathe, it moistens and warms or cools it and it means the body gets more nitric oxide, which broadens the blood vessels. Nitric oxide also decreases blood pressure, and some will know that it even helps medication like Viagra achieve success. I recommend that everyone experiments with their breathing. There’s so much to discover, so familiarise yourselves with the ideas of Wim Hof and the still relatively unknown Konstantin Buteyko. It’s really fun and can change your life.

Who knows more?

Kasper van der Meulen is my breathing guru. He offers really amazing breathing training in the Netherlands. He’s an extremely nice guy who is good at what he does. Find out more at kaspersfocus.com or find him at @kaspersfocus on Instagram.

FASTING: Cleanse, don’t eat

What’s in it for me?

Fasting is when the body gets no source of energy from solids or liquids. (Light is also really a form of energy but doesn’t count here.) After a while, the body begins to take the energy it needs from its reserves – and it has plenty of them. Glycogen in the muscles and liver gets depleted first and then, of course, there’s all that body fat, which even thin people have. But it’s all much smarter than the body just using up stored energy. While fasting, the body begins to break down its own cells and uses them to produce energy. The fascinating part is it burns only damaged cells – not fully operational ones. This process, known as autophagy, turns out to be the most efficient form of inner cleansing.

What should i do?

I eat O.M.A.D.—one meal a day—usually a very early dinner. Strictly speaking, I’m not fasting at all because I have coffee with butter and MCT [medium-chain triglyceride] oil in the morning and before noon. Fasting covers a fairly broad spectrum. For some it’s enough to avoid carbohydrates and protein, while others are more radical and think that even drinking tea or coffee or taking vitamins or magnesium would break the fast. But however you define it, start by skipping breakfast a couple of days a week (water, black coffee and unsweetened tea are fine). In step two, don’t eat the first meal of the day until at least 16 hours have passed since the last meal the day before.

Who knows more?

Julia Tulipan, of Vienna, Austria, is one of the top experts in ketogenic nutrition. The keto diet is sort of preliminary fasting, and Julia and her husband have brought their own Tulipans range of keto convenience foods to some supermarket shelves. Her website, juliatulipan.com, and Instagram feed, @paleolc, provide a lot of free German-language content and her Evolution Radio Show podcast [also in German] is fascinating listen.

FOREST: Green bathing

What’s in it for me?

The term ‘forest bathing’ has really taken off of late. It sounds spectacular, perhaps, but all it means in reality is going into the woods on a regular basis for a very slow and deliberate walk. What can that give a biohacker? Much more than you might think. The forest air contains thousands of terpenes, aromatic plant-based substances that fire our immune system and could even lower the risk of some cancers. The green of the forest and the natural calm reduce stress hormones—and not just during your forest bath because the reduction is still detectable for several days afterwards. Thorough research into forest bathing has been carried out in Japan and South Korea, where it’s applied as a recognised form of medicine. So in future, perhaps GPs will be telling their patients to take a hike, and I think that’s wonderful.

“In Japan and South Korea, doctors send their patients out for walks in the forest. ‘Shinrin-Yoku’, forest bathing, is a highly effective therapy.”

Aromas in the forest are even said to reduce the risk of cancer.

What should i do?

Walk through the forest for an hour or two a week, preferably alone and, importantly, without your mobile or any other electronic devices. It does everyone good. Ideally take a few steps barefoot or, if nobody is looking, hug a tree every now and again for the earthing and ion exchange, as mentioned above. But if you want to make your trip to the forest even better, the greatest concentration of terpenes occurs during misty or rainy weather. We humans have a need for nature. And once you learn—or relearn—to tune into it, you understand that your body has a sort of level indicator to show whether we have absorbed enough nature or not.

Who knows more?

Rolf Duda, aka Peakwolf, from Switzerland, is a former management consultant and a hero among biohackers. He has a soft spot for nature and the forest, but whatever he talks about, it’s always well-founded, intelligent and entertaining. I’m a true fan. His German-language website (peakwolf.ch) is a good introduction to Rolf’s world—from there you can go to his blog, podcast and Instagram feed.

WATER: 99/100

What’s in it for me?

Only every 100th molecule in our body isn’t a water molecule. Yes, you read that right. 99 out of 100 molecules in our body consist of two hydrogen and one oxygen atom. We humans are a (cleverly structured, admittedly) watery solution. So water is a prerequisite for everything working —every metabolic process, every detox, every nerve impulse, every thought, every emotion. Just a couple percent too little water in the body—I’m speaking one or two litres here—and our capacities are radically decreased.

What should i do?

Drink water. Personally, I drink filtered and revitalised water but in most countries you can mostly drink the tap water without a second thought. How much should you drink? Anything under 0.3 of a litre per 10 kilos of bodyweight is actively harmful to your performance and health. If you weigh 70 kilos, 2.1 litres a day is enough if you don’t work out, have almost no stress and don’t go to the sauna. But 0.3 litres per 10 kilos of bodyweight is the minimum. Make sure that you really drink enough for a full week. (Mostly in the morning so that your urine is very clear by noon.)

Who knows more?

Thomas Hartwig. His Berlin start-up Leogant creates perfect water filtration and treatment systems. Thomas is a water philosopher. The best sources of knowledge are the podcasts he has appeared on, such as the Flowgrade Show, with my friend Max Gotzler.

MEDITATION : The brain improver

What’s in it for me?

There’s not much more to add to what thousands upon thousands of studies confirm; meditation makes us smarter, happier and more creative. It’s probably the best and simplest thing we can do for our brain health. Meditation is something like the continuation of breathing and sleep’s little brother. There’s no right or wrong in meditating, and the only mistake you can make is not meditating regularly.

What should i do?

During my summer holiday last year, I did a sort of huge mindset reset where for two weeks solid I meditated my back side off for literally four, five, six hours a day. In my daily life, I now very consciously take a couple of minutes out, where I close my eyes, breathe in calmly and breathe out more calmly still, focusing solely on my breath. I really like playing around with the Muse headband that supervises how deep my meditation goes. There are some incredible meditations apps out there – and the best one that’s free of charge is Oak.

“If you want to take advantage of digital support: The best free meditation app is ‘Oak’, the best German-speaking one is ‘7Mind’.”

Apps and gadgets can be helpful meditation tools, according to Breitfeld.

Who knows more?

Germany’s Manuel Ronnefeldt, who founded the 7Mind meditation app – take a look at 7mind.de/en, where you’ll find a lot of free and detailed information.

HEAT: The life-lengthener

What’s in it for me?

Heat for free? Yes, by sitting in a thermal spring or going out in the blazing sun in the summer. Where I really like to go is the sauna. All types of sauna work, even though the effects differ depending on whether you’re using infrared or heated rocks – but the principle is the same. The main benefit is that sweating cleanses our bodies via its largest detoxifying organ, the skin. The second and third most important benefits (and there are a whole lot more besides) are an improved cardiovascular system and the so-called heat shock proteins the body forms. The sauna is, to put it simply, a boot camp workout for our cells. There are mind-blowing studies from Finland about how effective regular sauna visits are. The result is up to 40% lower mortality rates. In other words, during the reference period – the study ran for more than 20 years – regular sauna-¬goers reduced their risk of death by almost half.

What should i do?

My lab has an infrared sauna that I use several times a week. Sometimes I treat myself to a hot bath one to two hours before going to bed as perfect preparation for a good sleep. But, beware, heat and digestion do not make good bedfellows. Don’t go to the sauna for two, or even three, hours after eating. Heat means stress for the body, and you don’t digest well when stressed.

Who knows more?

Johannes Kettelhodt, the mastermind behind the Clearlight infrared cabin. He and his team have achieved something special. They make their saunas without creating any electric smog. That is a significant help as the body detoxes.

COLD: Inflammation’s natural enemy

What’s in it for me?

Inflammation can be a good thing because it triggers an alarm signal in the body at the start of a healing process. An injury doesn’t heal despite the inflammation; it heals because of the inflammation that forms around it. But inflammation can do serious long-term damage if it goes on too long. Low-threshold inflammation is definitely not something you want to have in your body, and the cold helps reduce it, while accelerating regeneration after sport and injury and improving the immune system. it stimulates the vagus nerve and with it our heart rate variability and ability to relax.

What should i do?

I take a five-minute ice-bath where the water is about 3°C almost every day in a repurposed deep-freeze in my lab. But how to get started? The easiest tip for beginners is to alternate your showers. At the end of your morning shower, just let the water run cold for 30 seconds and then do another 30 seconds in warm water. The hot-cold alternation is also very effective for recovery after sport. A little tip for amateur bodybuilders: taking a cold shower for longer than ten minutes (in 10°C water) or an ice-bath for longer than three minutes (in 3°C water) after training will make you recover more quickly, but it will also slow down muscle growth quite a lot, so take a shorter cold shower or only do the next cold therapy the following morning.

Who knows more?

Josephine Worseck, a doctor of molecular biology from Berlin, Germany, who specialises in the Wim Hof method. She’s also the author of a groundbreaking German-language book—Die Heilkraft der Kälte [The Healing Power of Cold]—which I thoroughly recommend, along with her workshops. There’s also a lot of content on Josephine’s website at: josephineworseck.com

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Biohacking of diets and how does it help?

This article is a repost which originally appeared on Times Of India

Edited for content.

Our Takeaways:

· Dieting is one of the most fundamental ways to transform the body

· Experimenting with eliminating certain foods from the diet can be helpful

· Fasting is an ancient and proven method towards preserving health and mental function

What Is Biohacking? If we bring down that term by hacking, we see that the bio has to do with our biology to do with our body? The way our body functions are natural processes in the body from eating to performance and so on and hacking is, of course, trying to decode something. Biohacking of diet is trying to use science or technology to improve our body’s functioning by way of eating. “I think our bodies are incredibly intelligent and given the right diet in the right lifestyle, we can elevate ourselves and feel amazing. Everyone has a scope of self-improvement and living their best life and biohacking of diets can make that possible without spending all money on fancy foods and a million different tools, gadgets and medicines to feel good. It’s a natural way to optimise the body’s performance,” says Nutritionist Ritu Khaneja

Diet Hack #1
Elimination Diet

An elimination diet is one where you can eliminate certain foods based on medical research to see if you react to them. You can generally start by eliminating the most common food allergens for a few weeks then you slowly add them back one at a time and note any symptoms better or worse. The main benefit is that by turning into a body’s reactions to certain foods you can’t pinpoint sensitivities and intolerances that you may not otherwise know of experiencing results.
It is less expensive and, in some cases, more reliable than standard allergy testing. It can also be very empowering to be in control of what you eat learn about food and the compounds they contain and try new recipes that exclude eliminated foods. Having a good diet plan makes things much easier and beneficial.

Diet Hack #2
Intermittent Fasting

There are several approaches to intermittent fasting but the easiest to achieve is the one that simply extends the usual timing of the night fast. A daily cycle of a 1 6 hour fast followed by an 8-hour eating window is usually sustainable for intermittent fasting. It must be combined with balanced meals that provide good nutrition. The goal of IF is to systematically starve the body long enough to trigger fat burning but the method may not be suitable for everyone. When done correctly intermission fasting can help lose weight, lower blood pressure and cholesterol, prevent or control diabetes and improve the brain’s health.

Diet Biohack#3
Adding More Fibre To The Diet

The normal fibre in our body has been eliminated just with the processing of food. One of the best way to eat fibre is by adding more fruits and vegetables to our diet. The benefits of fibre are weight control and maintaining bowel movements.lt also helps in lowering cholesterol and blood sugar levels.

Diet Hack #4
Adding Superfoods

The first step that I take to treat my clients through diet is adding superfoods. There is a whole list of superfoods with numerous benefits. 1 st category of superfoods is seeds not just any seeds but 2 seeds which one should hack into the diet are chia and flax. Chia seeds are a great source of omega 3 fatty acids, They have more calcium than milk and there are great sources of anti-inflammatory compounds. They’re great for growing skin and mental health and clarity and much much more. Flaxseeds are another great source for omega 3 fats and dietary fibre as well as essential vitamins minerals name powerful anti-cancer hormone-balancing compounds called lignans. It’s a great way of curing constipation as well.

Diet Biohack #5
Protein-Rich Diet

Eating plenty of high protein foods include a generous portion of at least 1 protein rich food at every meal will help you lose body fat or improve your body composition. Eating protein-rich meals can help you feel full and satisfied so you will eat less and lose weight. A high protein diet can help reduce insulin resistance so if you have diabetes or prediabetes, a high protein diet could be a good strategy for improving your blood sugar control.

To conclude, I think Biohacking of diet should be done mindfully as if something can be very beneficial for one body, It doesn’t mean it will suit everyone.

Calorie Restriction That Could Be Harnessed to Extend Healthy Lifespan in Humans

Decades of research has shown that limits on calorie intake by flies, worms, and mice can enhance life span in laboratory conditions. But whether such calorie restriction can do the same for humans remains unclear. Now a new study led by Yale researchers confirms the health benefits of moderate calorie restrictions in humans — and identifies a key protein that could be harnessed to extend health in humans.

This article is a repost which originally appeared on SciTechDaily
Yale University - February 20, 2022
Edited for content and readability - Images sourced from Pexels 
Source: DOI: 10.1126/science.abn6576

Our Takeaways:

  • The study observed the impact of calorie restriction to the immune and metabolic systems.
  • The thymus was analyzed – This is a gland that sits above the heart and produces T cells, a type of white blood cell and a part of the immune system. The thymus ages at a faster rate than other organs.
  • Results found that the thymus glands in participants with limited calorie intake had less fat and greater functionality after two years of calorie restriction.
  • Calorie restriction also reduced a specific protein gene PLA2G7 (a gene that impacts inflammation). Suppressing this gene in a different study protected aged mice from inflammation.

The research was based on results from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) clinical trial, the first controlled study of calorie restriction in healthy humans. For the trial, researchers first established baseline calorie intake among more than 200 study participants. The researchers then asked a share of those participants to reduce their calorie intake by 14% while the rest continued to eat as usual, and analyzed the long-term health effects of calorie restriction over the next two years.

The overall aim of the clinical trial was to see if calorie restriction is as beneficial for humans as it is for lab animals, said Vishwa Deep Dixit, the Waldemar Von Zedtwitz Professor of Pathology, Immunobiology, and Comparative Medicine, and senior author of the study. And if it is, he said, researchers wanted to better understand what calorie restriction does to the body specifically that leads to improved health.

Since previous research has shown that calorie restriction in mice can increase infections, Dixit also wanted to determine how calorie restriction might be linked to inflammation and the immune response.

“Because we know that chronic low-grade inflammation in humans is a major trigger of many chronic diseases and, therefore, has a negative effect on life span,” said Dixit, who is also director of the Yale Center for Research on Aging. “Here we’re asking: What is calorie restriction doing to the immune and metabolic systems and if it is indeed beneficial, how can we harness the endogenous pathways that mimic its effects in humans?”

Dixit and his team started by analyzing the thymus, a gland that sits above the heart and produces T cells, a type of white blood cell and an essential part of the immune system. The thymus ages at a faster rate than other organs. By the time healthy adults reach the age of 40, said Dixit, 70% of the thymus is already fatty and nonfunctional. And as it ages, the thymus produces fewer T cells. “As we get older, we begin to feel the absence of new T cells because the ones we have left aren’t great at fighting new pathogens,” said Dixit. “That’s one of the reasons why elderly people are at greater risk for illness.”

For the study, the research team used magnetic resonance imaging (MRI) to determine if there were functional differences between the thymus glands of those who were restricting calories and those who were not. They found that the thymus glands in participants with limited calorie intake had less fat and greater functional volume after two years of calorie restriction, meaning they were producing more T cells than they were at the start of the study. But participants who weren’t restricting their calories had no change in functional volume.

“The fact that this organ can be rejuvenated is, in my view, stunning because there is very little evidence of that happening in humans,” said Dixit. “That this is even possible is very exciting.”

With such a dramatic effect on the thymus, Dixit and his colleagues expected to also find effects on the immune cells that the thymus was producing, changes that might underlie the overall benefits of calorie restriction. But when they sequenced the genes in those cells, they found there were no changes in gene expression after two years of calorie restriction.

This observation required the researchers to take a closer look, which revealed a surprising finding: “It turns out that the action was really in the tissue microenvironment not the blood T cells,” Dixit said.

Dixit and his team had studied adipose tissue, or body fat, of participants undergoing calorie restriction at three time points: at the beginning of the study, after one year, and after two. Body fat is very important, Dixit said, because it hosts a robust immune system. There are several types of immune cells in fat, and when they are aberrantly activated, they become a source of inflammation, he explained.

“We found remarkable changes in the gene expression of adipose tissue after one year that were sustained through year two,” said Dixit. “This revealed some genes that were implicated in extending life in animals but also unique calorie restriction-mimicking targets that may improve metabolic and anti-inflammatory response in humans.”

Recognizing this, the researchers then set out to see if any of the genes they identified in their analysis might be driving some of the beneficial effects of calorie restriction. They honed in on the gene for PLA2G7 — or group VII A platelet activating factor acetylhydrolase — which was one of the genes significantly inhibited following calorie restriction. PLA2G7 is a protein produced by immune cells known as macrophages.

This change in PLA2G7 gene expression observed in participants who were limiting their calorie intake suggested the protein might be linked to the effects of calorie restriction. To better understand if PLA2G7 caused some of the effects observed with calorie restriction, the researchers also tracked what happened when the protein was reduced in mice in a laboratory experiment.

“We found that reducing PLA2G7 in mice yielded benefits that were similar to what we saw with calorie restriction in humans,” said Olga Spadaro, a former research scientist at the Yale School of Medicine and lead author of the study. Specifically, the thymus glands of these mice were functional for a longer time, the mice were protected from diet-induced weight gain, and they were protected from age-related inflammation.

These effects occurred because PLA2G7 targets a specific mechanism of inflammation called the NLRP3 inflammasome, researchers said. Lowering PLA2G7 protected aged mice from inflammation.

“These findings demonstrate that PLA2G7 is one of the drivers of the effects of calorie restriction,” said Dixit. “Identifying these drivers helps us understand how the metabolic system and the immune system talk to each other, which can point us to potential targets that can improve immune function, reduce inflammation, and potentially even enhance healthy lifespan.”

For instance, it might be possible to manipulate PLA2G7 and get the benefits of calorie restriction without having to actually restrict calories, which can be harmful for some people, he said.

“There’s so much debate about what type of diet is better — low carbohydrates or fat, increased protein, intermittent fasting, etc. — and I think time will tell which of these are important,” said Dixit. “But CALERIE is a very well-controlled study that shows a simple reduction in calories, and no specific diet, has a remarkable effect in terms of biology and shifting the immuno-metabolic state in a direction that’s protective of human health. So from a public health standpoint, I think it gives hope.”