Sean Jacobs
Retired Moderator, Member of the Month Dec 2012,
I was reading an interesting article on the Journal of Biological Chemistry website about smooth muscle cell growth. It appears that "mechanically stretching" of smooth muscle tissue can stimulate cell growth (both in the number of cells and the size of the cells).
Here is an excerpt from the article:
[h=2]RESULTS[/h]Mechanical Stretch of VSMCs Stimulates Cell Growth—VSMCs were mechanically stretched to stimulate cell growth. After 48 h of stretch, the cells exhibited a significant 5-fold increase in proliferating cell nuclear antigen expression when compared with non-stretched control cells (Fig. 1A). This would suggest that the stretched cells were actively entering the cell cycle. Cell counts confirmed that the cells were completing the cell cycle. There was a significant increase in cell number in a time-dependent manner as a function of the stretch stimulus (Fig. 1B). Both of these effects were blocked in the presence of a MAPK inhibitor PD98059 (Fig. 1, Aand B).Cell hypertrophy is another type of cell growth that may be stimulated by cell stretching. Cell hypertrophy was determined using the cytoplasmic probe calcein AM to measure total cell volume. Cells stimulated by stretching exhibited a significant increase in cell size compared with the non-stretched control group (Fig. 1C). This too was blocked in the presence of 1 μM PD98059. These results demonstrate that mechanical stretching is capable of inducing both hyperplasia and hypertrophy in the SMCs and that this appears to occur in an MAPK-dependent manner.
This could explain why PE works to increase penis size. We jelq, hang, stretch, pump, etc...which all, so some extent, stretch the cells of the smooth muscle tissue in the penis, which then induces the cells to create new cells and causes the cells to become larger.
Just an observation.
Here is an excerpt from the article:
[h=2]RESULTS[/h]Mechanical Stretch of VSMCs Stimulates Cell Growth—VSMCs were mechanically stretched to stimulate cell growth. After 48 h of stretch, the cells exhibited a significant 5-fold increase in proliferating cell nuclear antigen expression when compared with non-stretched control cells (Fig. 1A). This would suggest that the stretched cells were actively entering the cell cycle. Cell counts confirmed that the cells were completing the cell cycle. There was a significant increase in cell number in a time-dependent manner as a function of the stretch stimulus (Fig. 1B). Both of these effects were blocked in the presence of a MAPK inhibitor PD98059 (Fig. 1, Aand B).Cell hypertrophy is another type of cell growth that may be stimulated by cell stretching. Cell hypertrophy was determined using the cytoplasmic probe calcein AM to measure total cell volume. Cells stimulated by stretching exhibited a significant increase in cell size compared with the non-stretched control group (Fig. 1C). This too was blocked in the presence of 1 μM PD98059. These results demonstrate that mechanical stretching is capable of inducing both hyperplasia and hypertrophy in the SMCs and that this appears to occur in an MAPK-dependent manner.
This could explain why PE works to increase penis size. We jelq, hang, stretch, pump, etc...which all, so some extent, stretch the cells of the smooth muscle tissue in the penis, which then induces the cells to create new cells and causes the cells to become larger.
Just an observation.
