Chemical PE

[Iguana]

Good Luck Iguana. Where exactly are you injecting? Is this the same as injecting growth hormone?
What would happen if I injected growth hormone into my penis just once? You got me thinking man.

Thank you sir!

I'm injecting IGF-1 LR3. IGF is Insulin-like Growth Factor. It's the hormone that triggers cellular mitosis. It's not the same as HGH (human growth hormone) but acts in a similar way. HGH is actually metabolized by the liver, the liver then produces IGF-1. IGF-1 LR3 is a modified version of IGF-1 which substitutes an Arg for the Glu at position 3, as well as a 13 amino acid extension peptide at the N-terminus. This makes Long R3IGF-I significantly more potent (2-3x) than natural IGF-1.

IGF-1 builds new muscle tissue by promoting nitrogen retention and protein synthesis. This causes the growth of muscles through both hyperplasia (which is an increase in number of muscle cells) and mitogenesis (which is the actual growth of new muscle fibers). Thus IGF-1 not only makes muscle fibers bigger, it makes more of them as well! The great thing is that it binds to smooth muscle cells (found in the penis) in the same manner it binds to skeletal muscle cells.

To answer you question about injecting growth hormone into your penis just once, - nothing would happen. The growth process is slow (were dealing with microscopic cells here) and must be repeated over and over before growth is noticeable. I should start seeing girth gains in about 4-6 weeks. I'll keep you updated.


-Iguana

 

[JonPop]

Yeah, you keep us informed. Just the next time do it in plain English? Hee
By the way, congats on hitting 500 posts.

 

[slanker]

Iguana: thanks for the information. I see, IGF-1 should be the way to go hoping you achieve the desired results. I wander how many injections altogether, say a two month course?
What I also meant was where exactly on the penis do you inject? Some pics and diagrams to go with your descriptions would be nice.

 

[Iguana]

slanker, here's a link to Caverject's website. It contains instructions on how to inject. You have to be careful to avoid veins and nerves.
http://www.caverjectimpulse.com/content/Inj_Guide.pdf

I am injecting 3 times a week, so 2 months would be about 24 injections.



WARNING TO LURKERS and anyone else thinking of attempting this: I can't say this enough, if anyone gets the idea to inject Caverject or any other vasodilator, self-dosing can send you to the ER! Educate yourself throughly before attempting any of these methods. It is strongly advised to use Caverject under the supervision of a physician. An untreated priapism can cause you to loose your penis!

 

[Iguana]

IGF-1 Studies:

If you are considering IGF-1 these are definitely worth a read!

Aim. To investigate whether intracavernosal injection of IGF-1 protein can restore erectile function in the aging rat.

Results. After IGF-1 treatment, the ICP responses was significantly increased as the young control group in both the IGF-1 1 µg/kg and the IGF-1 10 µg/kg group compared with the vehicle-only group at 4 and 8 weeks (P < 0.05). Masson's trichrom staining showed the percentage of cavernosal smooth muscle was increased in IGF-1 treatment group. IGF-1 increased e-NOS expression. NOS activities and cGMP concentrations were also significantly increased in IGF-1 treatment rats.

Conclusions. IGF-1 improved erectile function in aged rats via restoration the integrity of smooth muscle of corpus cavernosum and modulation of NO-cGMP pathways. Pu, X-Y, Wang X-H, Gao W-C, Yang Z-H, and Li S-L. Insulin-like growth factor-1 restores erectile function in aged rats: Modulation the integrity of smooth muscle and nitric oxide-cyclic guanosine monophosphate signaling activity. J Sex Med **;**:**–**.

http://www.blackwell-synergy.com/do...09.2008.00817.x

I may have posted an exerpt from this study earlier. I ran across it again and wanted to re-post because this is such a definitive study. This was not done on rats, this was done on cultures of human corpus cavernosa smooth muscle cells. This pretty much says it all. IGF-1 does in fact increase smooth muscle cells.

Effects of Insulin-Like Growth Factor-1 on Proliferation of Human Corpus Cavernosal Smooth Muscle Cells.

Kim MK, Park K, Lee HS, Ahn K, Lee HC.

Department of Urology, Chonnam National University Medical School, Gwangju, Korea. [email protected]
Department of Microbiology, Chonnam National University Medical School, Gwangju, Korea.
Department of Anatomy, Chonnam National University Medical School, Gwangju, Korea.

PURPOSE: Insulin-like growth factor-1 (IGF-1) promotes the proliferation and migration of penile cavernous smooth muscle cells in the rat. The goals of this study were to evaluate the expression of IGF-1 and IGF-1 receptor (IGF-1R) in human corpus cavernosal smooth muscle cells (HCCSMCs) and to investigate the effect of IGF-1 on the proliferation of these cells in vitro. MATERIALS AND METHODS: The HCCSMCs were cultured from five impotent patients. The smooth muscle cells were identified by immunofluorescent stain. Total RNA was extracted, and IGF-1 gene expression was determined by RT-PCR. The IGF-1R immunoreactivity was examined by fluorescent Immunocytochemistry. Cell growth was assessed with a novel proliferation assay based on bioreduction of the fluorescent dye, Alamar blue. RESULTS: Endogenous IGF-1 mRNA expression was detected by RT-PCR analysis. The HCCSMCs were positive for IGF-IR. The proliferation of HCCSMCs increased with the dose in response IGF-1 in the culture medium in concentrations up to 100 ng/ml. CONCLUSIONS: Both IGF-1 and IGF-1R are expressed endogenously in human corpus cavernosal smooth muscle cells. IGF-1 promotes the proliferation of these cells in vitro.

 

[bpeemp]

Any updates???? Hows your injections going?

 

[Iguana]

Your timing on this is interesting. I had been taking a break since November. I'm scheduled to resume my injections starting today.

As far as what I might do differently this time:

I'm switching from using an extender to light prolonged hanging coupled with pumping. I plan on targeting my doses for
3-4 hour erections. Sometimes 4-6 hours depending on scheduling convenience.

I have enough chemicals to last about 6 months. I will re-evaluate at this point to see if it's worth continuing.

 

[shane_syndrome]

Iguana i have a few questions for you , if you dont mind answering them please.

1) are the injections painful

2) have you considered MGF (mechano growth factor) to use with igf , its common in body building to use them together

3)was your doctor on board with this right from the start


thanks

 

[Iguana]

Iguana i have a few questions for you , if you dont mind answering them please.

1) are the injections painful

2) have you considered MGF (mechano growth factor) to use with igf , its common in body building to use them together

3)was your doctor on board with this right from the start


thanks

Don't mind at all...

1.) No, not usually. It really depends on the injection location. Some parts of the tunica are thicker and harder to penetrate. Even the ones I would consider painful are only a slight feeling of a prick.

2.) Yes, I have looked in to MGF as a possibility. It's very similar to IGF-1. If fact, it's a variation of IGF-1 know as IGF-1Eb. It has been found to be upregulated by exercise or muscle damage.

I have also looked into another couple chemicals, one being PDGF-AA (platelet derived growth factor -AA.) Studies show it greatly increases the mitogenic effects of IGF-1. Results were "a strong increase in cell number."

Also, bFGF (basic Fibroblast Growth Factor.) Basic fibroblast growth factor (bFGF) is a mitogenic factor that is implicated in smooth muscle cell growth in atherosclerosis and vascular restenosis.

Maybe a combination of IGF-1, bFGF and PDGF would produce much better results? Just speculation.

But with everything chemical, there are risks: PDGF is known to be instrumental in angiogensis (the spontaneous growth and development of blood vessels.) This would explain why it would be beneficial in VSMG (vascular smooth muscle growth) and thus synergetic with IGF-1. It is however, like IGF-1, an huge risk to those with a family history or predisposition to cancer development as angiogensis is a known process in cancer development. Tumors signal this process to build vascular pathways for increased blood supply. So, like IGF-1, this chemical would be a definite no for those with cancer risks.

Incidentally, I found a few companies that sell an injectable research grade human PDGF recombinant. However we all know the dangers associated with research chemicals. I think I read a study where it was used in a clinical trial so a safer USP version may be available.

3.) My urologist prescribed the PGE-1 for bouts ED (most probably resulting from improper PE.) He has no idea of the enlargement prospects.


Hope this answers your questions!

 

[shane_syndrome]

thanks for the info , i have always been interested in steroids and growth factors.

i think it would be pretty hard to prick my dick tho but i guess its just hard the 1st and second time it would be hard until you get use to it.

i was just wondering how much the hole thing is costing you in total , i actually have igf on hand , i paid 170 for a 1000mcg Vial + BAC Water i have it to bring up my shoulders witch are lagging behind.

and are you mixing everything together or injecting them all separately.

I'm sorry about all the questions i am just a very curious person .

 

[Iguana]

No problem!

Actually, I was amazed at how pain free it was. I use a 30 gauge needle (very thin) and it's virtually painless (most of the time.)

You IGF-1 cost is pretty typical. I get my PGE-1 through my insurance so it's pretty affordable. I get 6 20mcg vials for $55.
BS water and syringes are cheap. It comes out to around $2.50 per injection.

I mix everything in one syringe in an effort to minimize sticks.

 

[shane_syndrome]

every thing i get is from a UG lab so i have to pay full price , luckily where I'm from i can just go to the pharmacy and get needles 10cents each

how about the caverject was that expensive and can it be replaced with an oral such as Cialis

 

[Iguana]

how about the caverject was that expensive and can it be replaced with an oral such as Cialis

PGE-1 is Caverject (brand name.) No Cialis and other PDE-5 based meds work very differently and cannot be substituted.

 

[shane_syndrome]

lol i feel kinda dumb now , but thanks i really hope it works out for you.

 

[shane_syndrome]

i checked the link you said (MTMC) and it says the location of there office is in Toronto and im only 30min away so i am considering checking it out

 

[Iguana]

Shane, yea check them out. I know a few guys who were patients of Dr Adams. Some have gotten pretty good results.
Let us know how it goes.

 

[shane_syndrome]

thanks , im on vacation in halifax , to visit some family but i will go in for sure in april when i get back home.
thanks

 

[profane]

iguana
how long have you been doing this? any gains so far?

 

[shane_syndrome]

I was talking to my friend about IGF and he was telling me that he took it for 8 weeks at 75iu's 5days a week and didn't really notice any gains until 6 months after , the reason behind this is because it takes along time for the new cells to mature.

 

[profane]

did he injected directly int he CC?