Key Takeaways:
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“If you look at the administration of rapamycin across about a billion years worth of evolutionary animal models, everything from yeast to worms, fruit flies to mammals (mice and dogs), this compound seems to universally increase life”.
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Rapamycin binds to a complex, called mTOR (mechanistic target of rapamycin) in our cells and inhibits its function.
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mTOR regulates autophagy
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When mTOR activity is turned down (by taking rapamycin), the body is more likely to undergo autophagy.
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Autophagy is the process by which cells eat themselves – the dysfunctional cells (like cancer cells) tend to be “eaten” first.
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In a sense – the inhibition of mTOR mimics what happens to the body in a nutrient sparse environment.
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Peter has been taking 5 mg of rapamycin for the last 3 months (he doesn’t specify how often, but it sounds like every 4-7 days).
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We can also suppress mTOR by fasting.
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Peter does a 1 week water only fast once per quarter, sandwiched on both sides by a week of following a ketogenic diet.
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“I think it’s really important to lift weights while fasting, because it really holds off the muscle mass loss”
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Cool Products and Supplements Mentioned:
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Flite Tabs to help protect against blood clots while flying
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Peter only trusts two branched-chain amino acid (BCAA) companies – Ajinomoto and Biosteel
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“I think there’s really some pretty good data on curcumin’s antinflammatory benefits, and in particular some much more compelling data on a formulation of it called Theracumin“
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Peter takes Pure Encapsulations Curcumin once per day.
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Peter takes Kirk Parsley’s Sleep Cocktail (a double dose) to help him fall asleep on planes
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He’s mentioned on other podcasts that he takes it every night before bed as well.
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*This article is a repost which originally appeared on the Podcast Notes Website.
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