Dr. Peter Attia on Longevity Compounds, Fasting, Supplements and More

Key Takeaways:
  • “If you look at the administration of rapamycin across about a billion years worth of evolutionary animal models, everything from yeast to worms, fruit flies to mammals (mice and dogs), this compound seems to universally increase life”.
  • Rapamycin binds to a complex, called mTOR (mechanistic target of rapamycin) in our cells and inhibits its function.
  • mTOR regulates autophagy
    • When mTOR activity is turned down (by taking rapamycin), the body is more likely to undergo autophagy.
      • Autophagy is the process by which cells eat themselves – the dysfunctional cells (like cancer cells) tend to be “eaten” first.
    • In a sense – the inhibition of mTOR mimics what happens to the body in a nutrient sparse environment.
  • Peter has been taking 5 mg of rapamycin for the last 3 months (he doesn’t specify how often, but it sounds like every 4-7 days).
  • We can also suppress mTOR by fasting.
  • Peter does a 1 week water only fast once per quarter, sandwiched on both sides by a week of following a ketogenic diet.
    • “I think it’s really important to lift weights while fasting, because it really holds off the muscle mass loss”
Cool Products and Supplements Mentioned:
  • Peter only trusts two branched-chain amino acid (BCAA) companies – Ajinomoto and Biosteel
  • “I think there’s really some pretty good data on curcumin’s antinflammatory benefits, and in particular some much more compelling data on a formulation of it called Theracumin
  • Peter takes Kirk Parsley’s Sleep Cocktail (a double dose) to help him fall asleep on planes
    • He’s mentioned on other podcasts that he takes it every night before bed as well.
*This article is a repost which originally appeared on the Podcast Notes Website.