Urethral/topical tadalafil(liquid cialis) application?

[8 x 8]

greetings.
if anyone knows the size of the tadalafil(liquid cialis) molecule, and whether or not a topical application inside the urethra, using no carrier, is:
1. possible
2. effective
3. if localized absorption is strong, how much to reduce dose by?
4. any side effects of this application?

if topical application of liquid cialis is not possible or has too many side effects this way:
1. can it be topically applied, with or w/o carrier, to the glans or shaft skin?
2. if a carrier is required for this method, which carrier is best?

thank you for any answers, questions, or comments.

 

[thesheet247]

I may be able to answer your question...

I may be able to answer your question...

Before I go and retrieve the answer to your question, I'd like to ask why you would choose to administer the chemical tadalafil citrate as a topical when it can simply be taken orally?

 

[JonPop]

Why would you risk an infection/severe irritation by sticking some unknown product into your urethra through your meatus?

 

[growing4her]

Off topic Jp but my wife saw a guy with a spoon shoved up there , then a guy with a pencil .

 

[JonPop]

Is your wife a nurse?

 

[growing4her]

Yes . I ask her alot of questions about this stuff , she understands the human body extremely well

 

[eompow]

Off topic Jp but my wife saw a guy with a spoon shoved up there , then a guy with a pencil .

In the ER truth is stranger than fiction.

 

[8 x 8]

Before I go and retrieve the answer to your question, I'd like to ask why you would choose to administer the chemical tadalafil citrate as a topical when it can simply be taken orally?

1. To keep the effects as localized as possible.
in addition to being a PDE5 blocker, tadalafil is a quasi-PDE11 blocker, and while there are no known side effects for this, PDE11 is involved in the kidneys, skeletal muscle, and other organs.
i'd rather keep my research as localized as possible.

Other unintended benefits might possibly be:
2. Faster action by the tadalafil on the glans and corpus (5 minutes instead of 45min)
3. Lower mg dose needed to achieve what 10-15mg can achieve thru an oral dose ($ savings)

That said, if their are serious drawbacks or irritation/contraindications to this method of urethral application, what carrier is needed to apply liquid cialis transdermally thru the glans or shaft skin? Again, thanks for any answers, discusiion, questions, or comments.

 

[8 x 8]

Transdermal Delivery of Tadalafil. I. Effect of Vehicles on Skin Permeation; Drug Development and Industrial Pharmacy - 35(3)ages 329-336 - Informa Healthcare

apparently, propolene glycol is a good method, but i do not have a prescription to this site, and would like to see a full text version for details.
If anyone can help with this, please let me know. thanks.

 

[8 x 8]

If anyone has any additional information on transdermal or urethral application of Cialis, please post it here, yes bump.

 

[8 x 8]

Well, I am considering ordering the powdered Tadalafil for researching this urethral/topical application style. After having found ChemOne's Liquid tadalafil to have good quality, will I be satisfied with the Powdered tadalafil from Elitenet pharm? Or does someone have a better source for the purest powdered tadalafil ?

 

[Jackxxx]

Sounds interesting. Good luck! Instead of buying bulk powder, you can just smash a generic tab and mix it with the carrier. Same sh*t. What are you planning to try as a carrier?

 

[Jackxxx]

Hey 8x8, I am working on a highly advanced and effective transdermal carrier. It works specifically for chemicals with a molecular weight of 500 or less. 300 or less ideal. Tadalafil has a molecular weight of 389.41, so it would work fine. However, the pure raw tadalafil powder would be better. Original Cialis prescription is mixed with several inactive ingredients.

For the topical solution, send me a PM for more info. Perhaps this thread should be moved to the science forum? A mod can decide that.

 

[JonPop]

Jack. I hope for your sake, (liability issues) that you aren't setting up your own little clinic on our site via PM's. (jP

 

[Jackxxx]

Jack. I hope for your sake, (liability issues) that you aren't setting up your own little clinic on our site via PM's. (jP

LOL. No. I don't have time for that. The only reason I share some information via PM, is because as some mods have stated, some information can be misused by young or unexperienced people and harm themselves. What I do and try, is a product of deep research, study, and personal experience. Is not something that anybody can just copy and paste and try it.

 

[TommyGUNZZZ]

still dont know why you are taking a constant dose of cialis/shoving it up your dick hole, from your other post you have told me that you can acheive a great effect with just the herbs. Why do you want this in your system as well?

 

[8 x 8]

still dont know why you are taking a constant dose of cialis/shoving it up your dick hole, from your other post you have told me that you can acheive a great effect with just the herbs. Why do you want this in your system as well?

I encourage you to re-read the other thread. What I have achieved is not the work of only herbs. Re-read it and you will see it is several techniques, in addition to a heavy supplementation of Amino acids/proteins, vitamins/minerals, certain foods, and of course, most importantly, specific herbs and TADALAFIL (Cialis). They all work in conjunction, and many are known cofactors (ginger root is a cofactor for anything with a limited half-life in our blood), and others I believe will be found to be co-factors with proper medical research.

In this thread I have already highlighted several reasons, for my upcoming tests for various urethral or transdermal application of tadalafil. I would recommend re-reading this thread also. There is alot of helpful information in the 2 threads. If you have any questions about either thread, please ask, I will do my best to answer them within a day or two. Ask away, as I'm sure others may have the same questions, and it would be helpful to everyone.

 

[8 x 8]

Hey 8x8, I am working on a highly advanced and effective transdermal carrier. It works specifically for chemicals with a molecular weight of 500 or less. 300 or less ideal. Tadalafil has a molecular weight of 389.41, so it would work fine. However, the pure raw tadalafil powder would be better. Original Cialis prescription is mixed with several inactive ingredients.

For the topical solution, send me a PM for more info. Perhaps this thread should be moved to the science forum? A mod can decide that.

I doubt I will be the GP, but I am curious nonetheless to see the caliber of your proposal.

 

[8 x 8]

Sounds interesting. Good luck! Instead of buying bulk powder, you can just smash a generic tab and mix it with the carrier. Same sh*t. What are you planning to try as a carrier?

I am going to avoid use of DMSO entirely except ofr a single reference dose as to compare the efficiacy of the other transdermal carriers in the test. Some are natural high-proof alcohols, others derivitaves of specific essential oils. Others are along the same lines as DMSO, just less efficient, and less dangerous. PEG400 will be one. I sent you a PM of another LOL (but seriously)

 

[8 x 8]

I have found something which is interesting regarding urethral/transdermal tadalafil application:

When I took Tadalafil orally, I noticed I got mild heartburn. Apparenty this is a symptom that occurs in some users, and I looked into why this is, and found some user-claims that Tadalafil caused esophageal erosion, so that immediately caused me to assume that it has a corrosive effect on mucous membranes, making the urethral application a big no-no, as I've already had a UTI, and don't want the burning urine again.

But after further research, the user's assumption was incorrect, the reason Tadalafil causes heartburn is not due to it having a corrosive force on the esophogus at all, it is due to it relaxing the lower esophogeal sphincter, which is the thing that opens when food enters the stomach, then closes as to not allow any food or stomach acid to come back up.

So, taking a urethral dose, will likely make the effects less systemic, and tending to be more localized, which would likely significantly lessen the heartburn inducing esophogeal-sphincter-relaxation.

Still waiting for the PM Jackxxx